February 28 ,2023
February 28 ,2023
Rosalind Elsie Franklin (London, 25 July 1920 – 16 April 1958) was a British chemist and X-ray crystallographer whose work was central to the understanding of the molecular structures of DNA (deoxyribonucleic acid), RNA (ribonucleic acid), viruses, coal, and graphite. Although her works on coal and viruses were appreciated in her lifetime, Franklin’s contributions to the discovery of the structure of DNA were largely unrecognized during her life, for which she has been variously referred to as the “wronged heroine”, the “dark lady of DNA”, the “forgotten heroine”, a “feminist icon”, and the “Sylvia Plath of molecular biology”.
Franklin graduated in 1941 with a degree in natural sciences from Newnham College, Cambridge, and then enrolled for a PhD in physical chemistry under Ronald George Wreyford Norrish, the 1920 Chair of Physical Chemistry at the University of Cambridge. Disappointed by Norrish’s lack of enthusiasm, she took up a research position under the British Coal Utilisation Research Association (BCURA) in 1942. The research on coal helped Franklin earn a PhD from Cambridge in 1945. Moving to Paris in 1947 as a chercheur (postdoctoral researcher) under Jacques Mering at the Laboratoire Central des Services Chimiques de l’État, she became an accomplished X-ray crystallographer. After joining King’s College London in 1951 as a research associate, Franklin discovered the key properties of DNA, which eventually facilitated the correct description of the double helix structure of DNA. Owing to disagreement with her director, John Randall, and her colleague Maurice Wilkins, Franklin was compelled to move to Birkbeck College in 1953.
Franklin is best known for her work on the X-ray diffraction images of DNA while at King’s College London, particularly Photo 51, taken by her student Raymond Gosling, which led to the discovery of the DNA double helix for which Francis Crick, James Watson, and Maurice Wilkins shared the Nobel Prize in Physiology or Medicine in 1962. Watson suggested that Franklin would have ideally been awarded a Nobel Prize in Chemistry, along with Wilkins but, although there was not yet a rule against posthumous awards, the Nobel Committee generally did not make posthumous nominations.
Working under John Desmond Bernal, Franklin led pioneering work at Birkbeck on the molecular structures of viruses. On the day before she was to unveil the structure of tobacco mosaic virus at an international fair in Brussels, Franklin died of ovarian cancer at the age of 37 in 1958. Her team member Aaron Klug continued her research, winning the Nobel Prize in Chemistry in 1982.